Sepsis Research Today is a free monthly online journal that collates and summarizes the latest research about Sepsis, including details on septicemia, diagnosis, symptoms, treatment.

Unexpected dramatic increase in CD4+ cell count in a patient with AIDS after enfuvirtide treatment despite persistent viremia and resistance mutations.

Soria A, Cavarelli M, Sala S, Alessandrini AI, Scarlatti G, Lazzarin A, Castagna A

Clinic of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy. soria.alessandro@hsr.it

An unexpected dramatic immune recovery was observed in a patient with full-blown AIDS receiving enfuvirtide-based antiretroviral therapy after multiple treatment failures. A complex interplay of viral and host factors, including the control of X4 viruses and proviral burden, may favor immune restoration with HIV neutralizing activity, despite persistent viremia.

Published 28 April 2008 in J Med Virol, 80(6): 937-41.
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