Sepsis Research Today is a free monthly online journal that collates and summarizes the latest research about Sepsis, including details on septicemia, diagnosis, symptoms, treatment.

Fatal levofloxacin failure in treatment of a bacteremic patient infected with Streptococcus pneumoniae with a preexisting parC mutation.

de Cueto M, Rodríguez JM, Soriano MJ, López-Cerero L, Venero J, Pascual A

Departamento de Microbiología, Hospital Virgen Macarena, Avda. Dr. Fedriani s/n, 41009 Seville, Spain. m@marinadecueto.e.telefonica.net

The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with a preexisting parC mutation is reported. Failure was due to the emergence of a gyrA mutation after 4 days of therapy. Problems encountered in detecting first-step mutation isolates are discussed.

Published 4 April 2008 in J Clin Microbiol, 46(4): 1558-60.
Full-text of this article is available online (may require subscription).

© 2004-2008 Sepsis Research Today. All Rights Reserved.