Sepsis Research Today is a free monthly online journal that collates and summarizes the latest research about Sepsis, including details on septicemia, diagnosis, symptoms, treatment.

Human recombinant activated protein C for severe sepsis.

Martí-Carvajal AJ, Solà I, Lathyris D, Cardona AF

Universidad de Carabobo and Iberoamerican Cochrane Network, Valencia, Edo. Carabobo, Venezuela.

Published 14 April 2011 in Cochrane Database Syst Rev, 4: CD004388.
Full-text of this article is available online (may require subscription).

Articles on Sepsis published 14 April 2011:

Human recombinant activated protein C for severe sepsis.   Cochrane Database Syst Rev, 4: CD004388.

[Abstract] [Full-text]

Articles on Sepsis published 13 April 2011:

Management of sepsis: a 47-year-old woman with an indwelling intravenous catheter and sepsis.   JAMA, 305(14): 1469-77.

Severe sepsis is the term used to describe the host response to infection when complicated by acute organ dysfunction. Severe sepsis occurs in more than 750,000 individuals in the United States each year, with a hospital mortality of about 30%. Although the classic presentation is of florid shock with frank hypotension, fever, and elevated white blood cell count, many patients can present with cryptogenic shock (shock without hypotension) with more subtle signs of vital organ compromise. Using ... [Abstract] [Full-text]

Management of sepsis: a 47-year-old woman with an indwelling intravenous catheter and sepsis.   JAMA, 305(14): 1469-77.

Severe sepsis is the term used to describe the host response to infection when complicated by acute organ dysfunction. Severe sepsis occurs in more than 750,000 individuals in the United States each year, with a hospital mortality of about 30%. Although the classic presentation is of florid shock with frank hypotension, fever, and elevated white blood cell count, many patients can present with cryptogenic shock (shock without hypotension) with more subtle signs of vital organ compromise. Using ... [Abstract] [Full-text]

Articles on Sepsis published 28 March 2011:

NKT cells: the culprits of sepsis?   J Surg Res, 167(1): 87-95.

Sepsis is currently a leading cause of death in hospital intensive care units. Previous studies suggest that the pathophysiology of sepsis involves the hyperactivation of complex pro-inflammatory cascades that include the activation of various immune cells and the exuberant secretion of pro-inflammatory cytokines by these cells. Natural killer T-cells (NKT) are a sub-lineage of T cells that share characteristics of conventional T cells and NK cells, and bridge innate and adaptive immunity. More ... [Abstract] [Full-text]

Articles on Sepsis published 11 March 2011:

Endocrine dysregulation in critically ill foals and horses.   Vet Clin North Am Equine Pract, 27(1): 35-47.

Critical illness challenges many endocrine homeostatic systems to overcome diseases, stress, and hostile conditions that threaten survival. Coordinated and consecutive responses by the autonomic nervous system, endocrine metabolic adaptations to mobilize and conserve energy and electrolytes, cardiovascular adjustments to maintain organ perfusion, and immunomodulation to overcome infections and inflammation are required. Because most admissions to equine intensive care units are related to ... [Abstract] [Full-text]

Articles on Sepsis published 4 March 2011:

Equine herpesvirus-1 infected peripheral blood mononuclear cell subpopulations during viremia.   Vet Microbiol, 149(1): 40-7.

Infection with equine herpesvirus-1 (EHV-1) causes respiratory disease, late term abortions and equine herpesvirus myeloencephalitis (EHM) and remains an important problem in horses worldwide. Despite increasing outbreaks of EHM in recent years, our understanding of EHM pathogenesis is still limited except for the knowledge that a cell-associated viremia in peripheral blood mononuclear cells (PBMCs) is a critical link between primary respiratory EHV-1 infection and secondary complications such ... [Abstract] [Full-text]

Articles on Sepsis published 14 February 2011:

Central line-associated bloodstream infections: prevention and management.   Infect Dis Clin North Am, 25(1): 77-102.

Approximately 80,000 central venous line-associated bloodstream infections (CLA-BSI) occur in the United States each year. CLA-BSI is most commonly caused by coagulase-negative staphylococci, Staphylococcus aureus, Candida spp, and aerobic gram-negative bacilli. These organisms commonly gain entrance in into the bloodstream via the catheter-skin interface (insertion site) or via the catheter hub. Use of strict aseptic technique for insertion is the key method for the prevention of CLA-BSI. ... [Abstract] [Full-text]

Articles on Sepsis published 8 February 2011:

Tracking changes of lymphocyte subsets and pre-inflammatory mediators in full-term neonates with suspected or documented infection.   Scand J Immunol, 73(3): 250-5.

Investigation was made of changes in immune system parameters during the course of neonatal infection. The study population consisted of 95 full-term neonates matched for chronological age and sex, divided into three groups: suspected infection (n=20), sepsis (n=25), infection-free control subjects (n=50). Serial measurements were made of the cytokines interleukin-6 (IL-6), interleukin-1b (IL-1b) and tumour necrosis factor-α (TNF-α), lymphocyte subsets [CD3+, CD4+, CD8+, natural killer (NK) ... [Abstract] [Full-text]

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